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Parahydrogen‐Induced Polarization Transfer to 19 F in Perfluorocarbons for 19 F NMR Spectroscopy and MRI
Author(s) -
Plaumann Markus,
Bommerich Ute,
Trantzschel Thomas,
Lego Denise,
Dillenberger Sonja,
Sauer Grit,
Bargon Joachim,
Buntkowsky Gerd,
Bernarding Johannes
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203455
Subject(s) - spin isomers of hydrogen , chemistry , chloroform , deuterium , polarization (electrochemistry) , hyperpolarization (physics) , spectroscopy , nuclear magnetic resonance spectroscopy , spectral line , nmr spectra database , analytical chemistry (journal) , nuclear magnetic resonance , hydrogen , stereochemistry , atomic physics , organic chemistry , physics , quantum mechanics , astronomy
Fluorinated substances are important in chemistry, industry, and the life sciences. In a new approach, parahydrogen‐induced polarization (PHIP) is applied to enhance 19 F MR signals of (perfluoro‐ n ‐hexyl)ethene and (perfluoro‐ n ‐hexyl)ethane. Unexpectedly, the end‐standing CF 3 group exhibits the highest amount of polarization despite the negligible coupling to the added protons. To clarify this non‐intuitive distribution of polarization, signal enhancements in deuterated chloroform and acetone were compared and 19 F– 19 F NOESY spectra, as well as 19 F T 1 values were measured by NMR spectroscopy. By using the well separated and enhanced signal of the CF 3 group, first 19 F MR images of hyperpolarized linear semifluorinated alkenes were recorded.