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Direct Conjugate Addition of Alkynes with α,β‐Unsaturated Carbonyl Compounds Catalyzed by NCN‐Pincer Ru Complexes
Author(s) -
Ito Junichi,
Fujii Kohei,
Nishiyama Hisao
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203380
Subject(s) - conjugate , chemistry , phosphonate , ketone , pincer movement , catalysis , alkyne , medicinal chemistry , addition reaction , organic chemistry , mathematical analysis , mathematics
NCN‐pincer Ru‐complexes containing bis(oxazolinyl)phenyl ligands serve as suitable catalysts in the direct conjugate additions of α,β‐unsaturated carbonyl compounds, including ketones, esters, and amides, as well as vinylphosphonates, giving various β‐alkynyl carbonyl and phosphonate compounds. A bis(oxazolinyl)phenyl (phebox)–Ru complex also catalyzes the asymmetric conjugate addition of an alkyne with a β‐substituted, α,β‐unsaturated ketone to produce a chiral β‐alkynyl ketone.