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Facile Access to 3‐Acylindoles through Palladium‐Catalyzed Addition of Indoles to Nitriles: The One‐Pot Synthesis of Indenoindolones
Author(s) -
Ma Yuanhong,
You Jingsong,
Song Feijie
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203354
Subject(s) - palladium , chemistry , catalysis , intramolecular force , substrate (aquarium) , combinatorial chemistry , selectivity , scope (computer science) , organic chemistry , computer science , oceanography , programming language , geology
Well‐connected : The palladium‐catalyzed addition of indoles to nitriles affords 3‐acylindoles. The reaction proceeds with high selectivity, wide substrate scope, broadly available starting materials, and an operationally simple procedure. Combination with the palladium‐catalyzed intramolecular oxidative coupling of 3‐indolylarylketone gives access to indenoindolones in a one‐pot synthesis.