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Design of Stable β‐Sheet‐Based Cyclic Peptide Assemblies Assisted by Metal Coordination: Selective Homo‐ and Heterodimer Formation
Author(s) -
Panciera Michele,
Amorín Manuel,
Castedo Luis,
Granja Juan R.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201203213
Subject(s) - supramolecular chemistry , octahedron , peptide , metal , beta sheet , materials science , hydrogen bond , crystallography , nanotechnology , single strand , chemistry , combinatorial chemistry , molecule , crystal structure , organic chemistry , biochemistry , dna
Metal‐directed supramolecular construction represents one of the most powerful tools to prepare a large variety of structures and functions. The ability of metals to organize different numbers and types of ligands with a variety of geometries (linear, trigonal, octahedral, etc.) expands the supramolecular synthetic architecture. We describe here the precise construction of homo‐ and heterodimeric cyclic peptide entities through coordination of a metal (Pd, Au) and to β‐sheet‐type hydrogen‐bonding interactions. The selective coordination properties of the appropriate metal allow control over the cross‐strand interaction between the two‐peptide strands.