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A Cyclometallated Platinum Complex as a Selective Optical Switch for Quadruplex DNA
Author(s) -
Suntharalingam Kogularamanan,
Łęczkowska Anna,
Furrer Mona A.,
Wu Yilei,
Kuimova Marina K.,
Therrien Bruno,
White Andrew J. P.,
Vilar Ramon
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202990
Subject(s) - dna , chemistry , nucleolus , platinum , confocal microscopy , biophysics , ligand (biochemistry) , nucleus , g quadruplex , confocal , in vitro , microbiology and biotechnology , biology , biochemistry , receptor , physics , optics , catalysis
Hits the spot : A cyclometalled platinum(II) complex with a substituted phenanthroline ligand is reported. The complex has high in vitro affinity for quadruplex DNA and upon binding its emission is switched on. The complex can be easily delivered to the cell by using a metallo‐cage as a carrier (see illustration). By means of confocal microscopy, it is shown that the complex is released inside the cell, penetrates the nucleus and localises in the nucleoli.