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Diversity‐Oriented Enantioselective Synthesis of Highly Functionalized Cyclic and Bicyclic Alcohols
Author(s) -
Mao Bin,
FañanásMastral Martín,
Lutz Martin,
Feringa Ben L.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202859
Subject(s) - enantioselective synthesis , bicyclic molecule , alkylation , alkyne , alkene , tsuji–trost reaction , reagent , stereoselectivity , chemistry , combinatorial chemistry , organic chemistry , catalysis
The copper‐catalyzed hetero ‐allylic asymmetric alkylation ( h ‐AAA) of functionalized Grignard reagents that contain alkene or alkyne moieties has been achieved with excellent regio‐ and enantioselectivity. The corresponding alkylation products were further transformed into a variety of highly functionalized cyclic and bicyclic alcohols with excellent control over the chemo‐, regio‐, and stereoselectivity.