Premium
Syntheses and Applications of Monofluorinated Cyclopropanes
Author(s) -
David Emilie,
Milanole Gaëlle,
Ivashkin Pavel,
CouveBonnaire Samuel,
Jubault Philippe,
Pannecoucke Xavier
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202831
Subject(s) - cyclopropane , ring (chemistry) , fluorine , chemistry , combinatorial chemistry , nanotechnology , organic chemistry , materials science
The combination of a fluorine atom and a cyclopropane ring, which both possess unique structural and chemical features, can generate new relevant building blocks for the discovery of efficient fluorinated biologically active agents. In this review, we report the different strategies to access monofluorocyclopropanes and highlight some of their attractive biological applications.