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A Bioinorganic View of Alzheimer’s Disease: When Misplaced Metal Ions (Re)direct the Electrons to the Wrong Target
Author(s) -
Faller Peter,
Hureau Christelle
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202697
Subject(s) - bioinorganic chemistry , metal ions in aqueous solution , metal , ion , oxidative stress , redox , chemistry , electron , disease , materials science , crystallography , inorganic chemistry , biochemistry , physics , medicine , quantum mechanics , organic chemistry
Metal ions Cu, Zn and Fe, seem to play a pivotal role in Alzheimer’s disease and other neurodegenerative diseases. In order to understand this in a broader sense, one has to considerer the peculiarities of metal metabolism in the brain compared to most other tissues, as well as the importance of the redox active metal ions, Fe and Cu, in oxygen metabolism and the connected oxidative stress.