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Synthesis of Imides by Palladium‐Catalyzed CH Functionalization of Aldehydes with Secondary Amides
Author(s) -
Bian YongJun,
Chen ChaoYue,
Huang ZhiZhen
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202601
Subject(s) - surface modification , palladium , catalysis , chemistry , combinatorial chemistry , catalytic cycle , organic chemistry
An efficient palladium‐catalyzed CH functionalization of aldehydes with various N‐substituted N ‐heteroarene‐2‐carboxamides has been developed for the synthesis of secondary imides. The reaction tolerates various functionalities, such as methoxy, fluoro, chloro, and bromo groups. A tentative radical mechanism for a Pd II /Pd IV catalytic cycle is proposed.