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Cobalt(II)‐Catalyzed 1,4‐Addition of Organoboronic Acids to Activated Alkenes: An Application to Highly cis ‐Stereoselective Synthesis of Aminoindane Carboxylic Acid Derivatives
Author(s) -
Chen MinHsien,
Mannathan Subramaniyan,
Lin PaoShun,
Cheng ChienHong
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202575
Subject(s) - stereoselectivity , chemistry , catalysis , cobalt , annulation , organic chemistry , carboxylic acid , medicinal chemistry
It all adds up : The 1,4‐addition of organoboronic acids to activated alkenes catalyzed by [Co(dppe)Cl 2 ] is described. A [3+2]‐annulation reaction of ortho ‐iminoarylboronic acids with acrylates to give various aminoindane carboxylic acid derivatives with cis ‐stereoselectivity is also demonstrated (see scheme; dppe=1,2‐bis(diphenylphosphino)ethane).