Premium
Poly(acrylic acid)‐Modified Fe 3 O 4 Microspheres for Magnetic‐Targeted and pH‐Triggered Anticancer Drug Delivery
Author(s) -
Kang XiaoJiao,
Dai YunLu,
Ma PingAn,
Yang DongMei,
Li ChunXia,
Hou ZhiYao,
Cheng ZiYong,
Lin Jun
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202433
Subject(s) - polyacrylic acid , dispersity , acrylic acid , materials science , polymer , polymerization , nanoparticle , hela , chemical engineering , drug delivery , polymer chemistry , nuclear chemistry , nanotechnology , chemistry , copolymer , composite material , biochemistry , engineering , cell
Monodisperse poly(acrylic acid)‐modified Fe 3 O 4 (PAA@Fe 3 O 4 ) hybrid microspheres with dual responses (magnetic field and pH) were successfully fabricated. The PAA polymer was encapsulated into the inner cavity of Fe 3 O 4 hollow spheres by a vacuum‐casting route and photo‐initiated polymerization. TEM images show that the samples consist of monodisperse porous spheres with a diameter around 200 nm. The Fe 3 O 4 spheres, after modification with the PAA polymer, still possess enough space to hold guest molecules. We selected doxorubicin (DOX) as a model drug to investigate the drug loading and release behavior of as‐prepared composites. The release of DOX molecules was strongly dependent on the pH value due to the unique property of PAA. The HeLa cell‐uptake process of DOX‐loaded PAA@Fe 3 O 4 was observed by confocal laser scanning microscopy (CLSM). After being incubated with HeLa cells under magnet magnetically guided conditions, the cytotoxtic effects of DOX‐loaded PAA@Fe 3 O 4 increased. These results indicate that pH‐responsive magnetic PAA@Fe 3 O 4 spheres have the potential to be used as anticancer drug carriers.