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Asymmetric Michael Reaction Catalyzed by Proline Lithium Salt: Efficient Synthesis of L ‐Proline and Isoindoloisoquinolinone Derivatives
Author(s) -
Xu Kun,
Zhang Sheng,
Hu Yanbin,
Zha Zhenggen,
Wang Zhiyong
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202409
Subject(s) - enantioselective synthesis , michael reaction , lithium (medication) , proline , catalysis , salt (chemistry) , chemistry , combinatorial chemistry , computer science , organic chemistry , biochemistry , psychology , amino acid , psychiatry
Lithium makes it possible : The enantioselective Michael addition of aldehydes to nitroalkenes was catalyzed by the readily available proline lithium salt. Remarkably, the asymmetric Michael reaction was scaled up to 50 mmol with 23:1 d.r. and 90 % ee.
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