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Organocatalyzed Enantioselective Desymmetrization of Diols in the Preparation of Chiral Building Blocks
Author(s) -
DíazdeVillegas María D.,
Gálvez José A.,
Badorrey Ramón,
LópezRamdeVíu M. Pilar
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202264
Subject(s) - desymmetrization , enantioselective synthesis , organocatalysis , chemistry , transformation (genetics) , field (mathematics) , combinatorial chemistry , organic chemistry , computer science , catalysis , mathematics , pure mathematics , biochemistry , gene
Desymmetrization of diols is a powerful tool to the synthesis of chiral building blocks. Among the different approaches to perform discrimination between both enantiotopic hydroxyl groups, the organocatalytic approach has gained importance in the last years. A diverse range of organocatalysts has been used to efficiently promote this enantioselective transformation and this Minireview examines the different contributions in this field.