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Biomimetic Oxidative Coupling of Benzylamines and 2‐Aminophenols: Synthesis of Benzoxazoles
Author(s) -
Endo Yoshinori,
Bäckvall JanE.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202187
Subject(s) - benzylamine , chemistry , oxidative coupling of methane , redox , catalysis , oxidative phosphorylation , combinatorial chemistry , organic chemistry , biochemistry
Aerobic oxidation : In a biomimetic approach, a mixture of redox catalysts forms couples that effect the aerobic oxidation of a mixture of benzylamine and 2‐aminophenol derivatives to give the corresponding benzoxazoles (see scheme). This biomimetic oxidation proceeds smoothly under mild conditions and the protocol can also be used for preparing benzimidazoles and benzothiazoles.