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Enantioselective Nickel‐Catalyzed Michael Additions of Azaarylacetates and Acetamides to Nitroalkenes
Author(s) -
Fallan Charlene,
Lam Hon Wai
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202093
Subject(s) - enantioselective synthesis , nickel , catalysis , michael reaction , combinatorial chemistry , chemistry , organic chemistry
Put a nickel in it : Azaarylacetates and acetamides, which have been neglected as substrates in catalytic asymmetric synthesis, undergo highly enantioselective Michael additions to nitroalkenes in the presence of a chiral nickel(II)‐bis(diamine) complex (see scheme; Bn=benzyl, MS=molecular sieves). This process is tolerant of a wide variety of azaarenes in the pronucleophile.