Premium
Synthesis and Biological Evaluation of a Library of Glycoporphyrin Compounds
Author(s) -
Daly Robin,
Vaz Gisela,
Davies Anthony M.,
Senge Mathias O.,
Scanlan Eoin M.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202064
Subject(s) - photodynamic therapy , porphyrin , trisaccharide , in vitro , chemistry , carbohydrate , biochemistry , cell culture , biological activity , basal cell , combinatorial chemistry , stereochemistry , biology , medicine , organic chemistry , pathology , genetics
A library of glycosylated porphyrins (glycoporphyrins) was prepared and the compounds were evaluated for their photodynamic therapy (PDT) activity against the oesophageal squamous‐cell carcinoma cell line OE21 in vitro. A synthetic methodology was developed to allow incorporation of biologically active carbohydrates, including the histo‐blood‐group antigen trisaccharide Lewis X , onto the porphyrin backbone. The effect of the carbohydrate group and substitution pattern on the PDT activity, cell uptake and subcellular localisation of the glycoporphyrin compounds is reported.