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Palladium‐Catalyzed Cross‐Coupling Reactions of Electron‐Deficient Alkenes with N ‐Tosylhydrazones: Functional‐Group‐Controlled CC Bond Construction
Author(s) -
Jiang Huanfeng,
Fu Wei,
Chen Huoji
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202051
Subject(s) - palladium , chemistry , functional group , cascade , catalysis , coupling reaction , stereoselectivity , coupling (piping) , group (periodic table) , electron , medicinal chemistry , computational chemistry , organic chemistry , materials science , physics , chromatography , quantum mechanics , metallurgy , polymer
In the zone : A palladium‐catalyzed cross‐coupling reaction of electron‐deficient alkenes with N ‐tosylhydrazones, which affords diverse CC bonds resulting from the functional‐group‐controlled effect, is reported (see scheme). These cascade transformations present remarkable stereoselectivity and a high synthetic potential. The presence of water substantially promotes both reaction routes.