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Neutral 1,3‐Diindolylureas for Nerve Agent Remediation
Author(s) -
BarbaBon Andrea,
Costero Ana M.,
Parra Margarita,
Gil Salvador,
MartínezMáñez Ramón,
Sancenón Félix,
Gale Philip A.,
Hiscock Jennifer R.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201202028
Subject(s) - nerve agent , scheme (mathematics) , environmental remediation , hydrolysis , mechanism (biology) , quality (philosophy) , chemistry , computer science , combinatorial chemistry , philosophy , organic chemistry , mathematics , biology , epistemology , mathematical analysis , ecology , contamination , acetylcholinesterase , enzyme
Efficient neutralization of nerve‐agent simulants by 1,3‐diindolylureas in a neutral medium was investigated (see scheme; DCP=diethylchlorophosphate, DCNP=diethylcyanophosphonate). The rate of hydrolysis of the simulants was found to increase by as much as 45 % in the presence of these compounds. A mechanism based on the simulant complexation was established.