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Palladium‐Catalyzed Dehydrogenative β′‐Arylation of β‐Keto Esters under Aerobic Conditions: Interplay of Metal and Brønsted Acids
Author(s) -
Yip KaiTai,
Nimje Roshan Y.,
Leskinen Mikko V.,
Pihko Petri M.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201988
Subject(s) - catalysis , palladium , regioselectivity , phenols , brønsted–lowry acid–base theory , chemistry , organic chemistry , metal , combinatorial chemistry
The Brønsted aids : The first dehydrogenative arylation of β‐keto esters with arenes under ambient aerobic conditions is described (see scheme). Under a Pd II /Brønsted acid co‐catalytic system, regioselective arylations with alkoxylated arenes and phenols were achieved in good yields, even in gram‐scale conditions.