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“Organo–Metal” Synergistic Catalysis: The 1+1>2 Effect for the Construction of Spirocyclopentene Oxindoles
Author(s) -
Sun Wangsheng,
Zhu Gongming,
Wu Chongyang,
Hong Liang,
Wang Rui
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201976
Subject(s) - oxindole , catalysis , chemistry , function (biology) , combinatorial chemistry , metal , action (physics) , computer science , organic chemistry , physics , biology , quantum mechanics , evolutionary biology
Synergy in action : A highly efficient “organo–metal” synergistic catalysis strategy for the synthesis of spirocyclopentene oxindole derivatives has been developed (see scheme). The lower overall d.r. and ee obtained from the stepwise approach (4:1 vs. 8:1 d.r.; 71 vs. >99 % ee ) suggest that both catalysts function more efficiently when combined, compared with the separate catalytic approach, and show an evident 1+1>2 synergistic effect for the construction of spirocyclopentene oxindoles.