Hypoxia‐Selective DNA Interstrand Cross‐Link Formation by Two Modified Nucleosides | Zendy

Kuang Yunyan | Zendy; Sun Huabing | Zendy; Blain J. Craig | Zendy; Peng Xiaohua | Zendy

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Hypoxia‐Selective DNA Interstrand Cross‐Link Formation by Two Modified Nucleosides

Author(s) -

Kuang Yunyan,

Sun Huabing,

Blain J. Craig,

Peng Xiaohua

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201201960

Subject(s) - chemistry , dna , nitroimidazole , photodissociation , yield (engineering) , stereochemistry , photochemistry , biochemistry , organic chemistry , materials science , metallurgy

The clean crossed code : Two nitroimidazole‐modified thymidines 1 a and 1 b were synthesized and incorporated into DNA oligomers. The 350 nm photolysis of 1 a and 1 b generated a 5‐(2′‐deoxyuridinyl)methyl radical that induced DNA interstrand cross‐links (ICL; see scheme). A higher ICL yield was observed under hypoxic conditions than under aerobic conditions.

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