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Iron Metal–Organic Frameworks MIL‐88B and NH 2 ‐MIL‐88B for the Loading and Delivery of the Gasotransmitter Carbon Monoxide
Author(s) -
Ma Mingyan,
Noei Heshmat,
Mienert Bernd,
Niesel Johanna,
Bill Eckhard,
Muhler Martin,
Fischer Roland A.,
Wang Yuemin,
Schatzschneider Ulrich,
MetzlerNolte Nils
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201743
Subject(s) - carbon monoxide , materials science , fourier transform infrared spectroscopy , metal organic framework , crystallinity , biocompatibility , chemical engineering , nanotechnology , chemistry , organic chemistry , catalysis , metallurgy , composite material , adsorption , engineering
Crystals of MIL‐88B‐Fe and NH 2 ‐MIL‐88B‐Fe were prepared by a new rapid microwave‐assisted solvothermal method. High‐purity, spindle‐shaped crystals of MIL‐88B‐Fe with a length of about 2 μm and a diameter of 1 μm and needle‐shaped crystals of NH 2 ‐MIL‐88B‐Fe with a length of about 1.5 μm and a diameter of 300 nm were produced with uniform size and excellent crystallinity. The possibility to reduce the as‐prepared frameworks and the chemical capture of carbon monoxide in these materials was studied by in situ ultrahigh vacuum Fourier‐transform infrared (UHV‐FTIR) spectroscopy and Mössbauer spectroscopy. CO binding occurs to unsaturated coordination sites (CUS). The release of CO from the as‐prepared materials was studied by a myoglobin assay in physiological buffer. The release of CO from crystals of MIL‐88B‐Fe with t 1/2 =38 min and from crystals of NH 2 ‐MIL‐88B‐Fe with t 1/2 =76 min were found to be controlled by the degradation of the MIL materials under physiological conditions. These MIL‐88B‐Fe and NH 2 ‐MIL‐88B‐Fe materials show good biocompatibility and have the potential to be used in pharmacological and therapeutic applications as carriers and delivery vehicles for the gasotransmitter carbon monoxide.