Rapid and Specific Post‐Synthesis Modification of DNA through a Biocompatible Condensation of 1,2‐Aminothiols with 2‐Cyanobenzothiazole | Zendy

Cheng Yunfeng | Zendy; Peng Hanjing | Zendy; Chen Weixuan | Zendy; Ni Nanting | Zendy; Ke Bowen | Zendy; Dai Chaofeng | Zendy; Wang Binghe | Zendy

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Rapid and Specific Post‐Synthesis Modification of DNA through a Biocompatible Condensation of 1,2‐Aminothiols with 2‐Cyanobenzothiazole

Author(s) -

Cheng Yunfeng,

Peng Hanjing,

Chen Weixuan,

Ni Nanting,

Ke Bowen,

Dai Chaofeng,

Wang Binghe

Publication year - 2013

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201201677

Subject(s) - surface modification , chemistry , combinatorial chemistry , dna , condensation , yield (engineering) , dna synthesis , materials science , biochemistry , physics , metallurgy , thermodynamics

Post‐synthesis modification of DNA is an important way of functionalizing DNA molecules. Herein, we describe a method that first enzymatically incorporates a cyanobenzothiazole (CBT)‐modified thymidine. The side‐chain handle CBT can undergo a rapid and site‐specific cyclization reaction with 1,2‐aminothiols to afford DNA functionalization in aqueous solution. Another key advantage of this method is the formation of a single stereo/regioisomer in the process, which allows for precise control of DNA modification to yield a single component for aptamer selection work and other applications.

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