Premium
Cooperative Switching Events in Azobenzene Foldamer Denaturation
Author(s) -
Yu Zhilin,
Hecht Stefan
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201624
Subject(s) - azobenzene , photoisomerization , foldamer , cooperativity , computer science , chemistry , crystallography , isomerization , molecule , organic chemistry , biochemistry , catalysis
Insight into the mechanism of photoswitchable foldamer denaturation was gained by incorporating two azobenzene switching units (see figure; orange) into the helix backbone. Optimizing the location of the units leads to cooperative photoisomerization events, causing complete unfolding. The switching cooperativity coupled with the cooperative unfolding transition enables the design of highly photosensitive systems.