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Nitric Oxide Donor‐Based Platinum Complexes as Potential Anticancer Agents
Author(s) -
Zhao Jian,
Gou Shaohua,
Sun Yanyan,
Yin Runting,
Wang Zhimei
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201605
Subject(s) - carboplatin , moiety , platinum , chemistry , nitric oxide , cytotoxicity , combinatorial chemistry , aqueous solution , nitrate , stereochemistry , organic chemistry , biochemistry , in vitro , cisplatin , chemotherapy , biology , catalysis , genetics
Joining forces : Platinum complexes containing organic nitrate ligands were investigated as anticancer agents. The complexes, which were stable in aqueous solution, showed cytotoxicity that was superior to that of the corresponding parent compound (carboplatin), thus suggesting an interesting synergy between the ability of the nitrate‐based ligands to release nitric oxide and the ability of the platinum moiety to inhibit DNA synthesis (see scheme).