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Catalytic Enantioselective tert ‐Aminocyclization by Asymmetric Binary Acid Catalysis (ABC): Stereospecific 1,5‐Hydrogen Transfer
Author(s) -
Chen Liujuan,
Zhang Long,
Lv Jian,
Cheng JinPei,
Luo Sanzhong
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201532
Subject(s) - stereospecificity , enantioselective synthesis , catalysis , scope (computer science) , substrate (aquarium) , chemistry , binary number , combinatorial chemistry , stereochemistry , computer science , organic chemistry , mathematics , arithmetic , biology , ecology , programming language
Selective H transfer by ABC : A new asymmetric binary acid catalyst was developed to promote 1,5‐H transfer specifically and stereoselectively in tert ‐aminocyclization reactions with excellent activity, high enantioselectivity, and broad substrate scope. The H atom (in red) was proven to transfer through a stereospecific suprafacial pathway (see scheme).