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Preparation of Highly Functionalised Benzofurans from ortho ‐Hydroxyphenones and Dichloroethylene: Applications and Mechanistic Investigations
Author(s) -
Schevenels Florian,
Tinant Bernard,
Declercq JeanPaul,
Markó István E.
Publication year - 2013
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201505
Subject(s) - benzofuran , furan , chemistry , organic chemistry , combinatorial chemistry
Highly functionalised benzofurans have been prepared from ortho ‐hydroxyphenones and 1,1‐dichloroethylene. The key intermediate, a chloromethylene furan, smoothly rearranged into the corresponding benzofuran carbaldehyde under acidic conditions. Some mechanistic investigations have been performed and several biologically active benzofurans have been synthesised.