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A New Highly Versatile Handle for Chemistry on a Solid Support: The Pipecolic Linker
Author(s) -
Masurier Nicolas,
Zajdel Paweł,
Verdié Pascal,
Pawłowski Maciej,
Amblard Muriel,
Martinez Jean,
Subra Gilles
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201452
Subject(s) - linker , pipecolic acid , lysine , residue (chemistry) , computer science , chemistry , solid phase synthesis , combinatorial chemistry , amino acid , peptide , biochemistry , programming language
The versatility of the pipecolic linker (Pip‐linker) is illustrated by the synthesis of modified amino acids, C‐terminal‐modified pseudopeptides, and cyclic peptides, through side‐chain anchoring of a lysine residue (see figure). Introduction of the first residue was easily accomplished and the Pip‐linker revealed to be robust enough to support various chemical modifications.