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Structure‐Directing Agents for the Synthesis of TiO 2 ‐Based Drug‐Delivery Systems
Author(s) -
Ghedini Elena,
Nichele Valentina,
Signoretto Michela,
Cerrato Giuseppina
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201355
Subject(s) - drug delivery , physisorption , pulmonary surfactant , materials science , chemical engineering , mesoporous material , drug , drug carrier , ibuprofen , nanotechnology , fourier transform infrared spectroscopy , kinetics , chemistry , organic chemistry , catalysis , pharmacology , medicine , engineering , physics , quantum mechanics
A series of titanium oxides was prepared by using a surfactant‐template method (STM) and used as a carrier for the sustained release of ibuprofen, which was chosen as a model drug. This STM provides an efficient route to TiO 2 matrices with both high surface area (when compared with those that were obtained by using traditional synthetic approaches) and well‐defined mesoporous textures. Some parameters of the synthetic procedure were varied: pH value, surfactant, and thermal treatment. The physicochemical nature of the surface carriers were investigated by means of N 2 ‐physisorption measurements and FTIR spectroscopy. The effect of the amount of drug on the release kinetics was also investigated. The drug delivery was evaluated in vitro in four different physiological solutions (that simulated the gastrointestinal tract) to analyze the behavior of the TiO 2 ‐based systems if they were to be formulated as oral DDSs. Our optimized approach is a good alternative to the classical methods that are used to prepare efficient TiO 2 ‐based drug‐delivery systems.