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pH‐Dependent Release of Doxorubicin from Fast Photo‐Cross‐Linkable Polymersomes Based on Benzophenone Units
Author(s) -
Yassin Mohamed A.,
Appelhans Dietmar,
Mendes Rafael G.,
Rümmeli Mark H.,
Voit Brigitte
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201312
Subject(s) - polymersome , benzophenone , doxorubicin , chemistry , computer science , nanotechnology , biophysics , polymer chemistry , materials science , copolymer , polymer , organic chemistry , surgery , medicine , amphiphile , chemotherapy , biology
Conditional release : pH‐Sensitive polymersomes are stabilized by cross‐linking through short UV irradiation for reversible swelling/shrinking upon switching the pH. The membrane of these polymersomes behaves as a gate, which traffics the release of small bioactive molecules, such as doxorubicin from the lumen of polymersomes depending on cross‐linking density and external pH (see scheme).