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Synthesis of Aza‐Fused Polycyclic Quinolines via Double CH Bond Activation
Author(s) -
Huang JiRong,
Dong Lin,
Han Bo,
Peng Cheng,
Chen YingChun
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201207
Subject(s) - aryl , chemistry , combinatorial chemistry , heteroatom , rhodium , stereochemistry , organic chemistry , catalysis , ring (chemistry) , alkyl
Simple but efficient : Aza‐fused polycyclic quinolines were efficiently assembled through rhodium(III)‐based direct double CH activation of N ‐aryl azoles followed by cyclization with alkynes without heteroatom‐assisted chelation. Copper(II) acetate, aside from acting as an oxidant, could also play an important role in the CH activation process.