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Transition Metal and Hydrogen Bond Donor Hybrids: Catalysts for the Activation of Alkylidene Malonates
Author(s) -
Nickerson David M.,
Mattson Anita E.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201206
Subject(s) - urea , thiourea , palladium , catalysis , nucleophile , chemistry , yield (engineering) , transition metal , reactivity (psychology) , combinatorial chemistry , organic chemistry , medicinal chemistry , materials science , medicine , alternative medicine , pathology , metallurgy
Palladium ureaka ! Urea palladacycles are introduced to activate alkylidene malonates for nucleophilic attack. The strategic incorporation of palladium on a urea scaffold give rise to urea catalysts with enhanced reactivity when compared to conventional urea and thiourea catalysts. A variety of alkylidene malonates are easily activated with urea palladacycle catalysts giving rise to the corresponding products in high yield (see scheme).