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Direct Amidation of Alcohols with N‐Substituted Formamides under Transition‐Metal‐Free Conditions
Author(s) -
Xu Kun,
Hu Yanbin,
Zhang Sheng,
Zha Zhenggen,
Wang Zhiyong
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201203
Subject(s) - formamides , transition metal , chemistry , tandem , organic chemistry , combinatorial chemistry , materials science , catalysis , composite material
Go tandem! The first example of the direct amidation of alcohols with N‐substituted formamides has been developed. A series of tertiary amides, including the challenging N , N ‐dimethyl‐substituted amides, were obtained in moderate to good yields under transition‐metal‐free conditions (see scheme). TBHP= tert ‐butyl hydroperoxide.
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