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An Acid‐Catalyzed Cyclialkylation that Provides Rapid Access to a Twisted Molecular Basket
Author(s) -
Hermann Keith,
Turner Daniel A.,
Hadad Christopher M.,
Badjić Jovica D.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201153
Subject(s) - scope (computer science) , cavitand , simple (philosophy) , computer science , combinatorial chemistry , catalysis , twist , world wide web , chemistry , organic chemistry , molecule , mathematics , programming language , philosophy , epistemology , supramolecular chemistry , geometry
Twist of fate : Expanding the scope of cavity‐containing compounds is essential for developing more efficient sensors and catalysts. This report describes an efficient cyclialkylation reaction that provides rapid access to a novel C 3 symmetric and chiral cavitand (see figure). The host can be prepared in larger quantities through two synthetic steps and from simple starting materials.