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Reactivity of Nucleosides with a Hydroxyl Radical in Non‐aqueous Medium
Author(s) -
RodríguezMuñiz Gemma M.,
Marin M. Luisa,
LhiaubetVallet Virginie,
Miranda Miguel A.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201090
Subject(s) - reactivity (psychology) , nucleobase , chemistry , aqueous solution , acetonitrile , aqueous medium , deoxyribonucleosides , organic chemistry , combinatorial chemistry , dna , biochemistry , medicine , alternative medicine , pathology , enzyme
DNA damage : The reactivity of HO . with silylated 2′‐deoxyribonucleosides was investigated in acetonitrile by means of a time‐resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC‐MS revealed that HO . attack occurred at the nucleobase (see scheme).