Reactivity of Nucleosides with a Hydroxyl Radical in Non‐aqueous Medium | Zendy

RodríguezMuñiz Gemma M. | Zendy; Marin M. Luisa | Zendy; LhiaubetVallet Virginie | Zendy; Miranda Miguel A. | Zendy

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Reactivity of Nucleosides with a Hydroxyl Radical in Non‐aqueous Medium

Author(s) -

RodríguezMuñiz Gemma M.,

Marin M. Luisa,

LhiaubetVallet Virginie,

Miranda Miguel A.

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201201090

Subject(s) - reactivity (psychology) , nucleobase , chemistry , aqueous solution , acetonitrile , aqueous medium , deoxyribonucleosides , organic chemistry , combinatorial chemistry , dna , biochemistry , medicine , alternative medicine , pathology , enzyme

DNA damage : The reactivity of HO . with silylated 2′‐deoxyribonucleosides was investigated in acetonitrile by means of a time‐resolved technique. The obtained rate constants were in general slightly lower than those reported for the natural nucleosides in water. Analysis of the reaction mixture by UPLC‐MS revealed that HO . attack occurred at the nucleobase (see scheme).

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