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Establishing a Flow Process to Coumarin‐8‐Carbaldehydes as Important Synthetic Scaffolds
Author(s) -
Zak Jaroslav,
Ron David,
Riva Elena,
Harding Heather P.,
Cross Benedict C. S.,
Baxendale Ian R.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201201039
Subject(s) - coumarin , aldehyde , flow chemistry , combinatorial chemistry , computer science , continuous flow , work flow , process (computing) , product (mathematics) , flow (mathematics) , chemistry , process engineering , biochemical engineering , organic chemistry , engineering , manufacturing engineering , catalysis , mathematics , operating system , geometry
Despite their usefulness as fluorophores and synthetic precursors, efficient and reliable routes to coumarin‐8‐carbaldehydes are lacking. We describe here a high‐yielding continuous flow synthesis that requires no manual intermediate purification or work‐up, giving access to multigram quantities of the aldehyde product.