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Highly Enantioselective Epoxidation of Multisubstituted Enones Catalyzed by Non‐Heme Iron Catalysts
Author(s) -
Wang Bin,
Wang Shoufeng,
Xia Chungu,
Sun Wei
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200992
Subject(s) - enantioselective synthesis , catalysis , benzimidazole , enantiomer , combinatorial chemistry , chemistry , heme , enantiomeric excess , proline , organic chemistry , amino acid , biochemistry , enzyme
Iron(II) efficiency : The iron complexes of N 4 ligands, derived from proline and benzimidazole, exhibited an unprecedented activity and enantioselectivity for the epoxidation of a variety of di‐ and trisubstituted enones (see scheme). This system, based on synthetic non‐heme iron catalysts, provides ready access to a wide range of epoxyketones of high enantiomeric purity.