Highly Enantioselective Iridium‐Catalyzed Hydrogenation of α,β‐Unsaturated Esters | Zendy

Li JiaQi | Zendy; Quan Xu | Zendy; Andersson Pher G. | Zendy

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Highly Enantioselective Iridium‐Catalyzed Hydrogenation of α,β‐Unsaturated Esters

Author(s) -

Li JiaQi,

Quan Xu,

Andersson Pher G.

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201200907

Subject(s) - iridium , enantioselective synthesis , catalysis , asymmetric hydrogenation , chemistry , organic chemistry , carbon fibers , combinatorial chemistry , materials science , composite number , composite material

α,β‐Unsaturated esters have been employed as substrates in iridium‐catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee ) were obtained for a broad range of substrates with both aromatic‐ and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.

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