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Highly Enantioselective Iridium‐Catalyzed Hydrogenation of α,β‐Unsaturated Esters
Author(s) -
Li JiaQi,
Quan Xu,
Andersson Pher G.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200907
Subject(s) - iridium , enantioselective synthesis , catalysis , asymmetric hydrogenation , chemistry , organic chemistry , carbon fibers , combinatorial chemistry , materials science , composite number , composite material
α,β‐Unsaturated esters have been employed as substrates in iridium‐catalyzed asymmetric hydrogenation. Full conversions and good to excellent enantioselectivities (up to 99 % ee ) were obtained for a broad range of substrates with both aromatic‐ and aliphatic substituents on the prochiral carbon. The hydrogenated products are highly useful as building blocks in the synthesis of a variety of natural products and pharmaceuticals.