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Mechanistic Insights into the Role of Chiral Ligands in Asymmetric Diamination Reactions
Author(s) -
Jindal Garima,
Sunoj Raghavan B.
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200872
Subject(s) - phosphoramidite , chemistry , enantioselective synthesis , combinatorial chemistry , asymmetric hydrogenation , diamine , catalysis , organic chemistry , biochemistry , dna , oligonucleotide
DFT holds the key : The most recent developments in Pd‐catalyzed asymmetric syntheses of diamines by using phosphoramidite ligands offer promising avenues to access chiral diamines. The molecular‐level insights on the transfer of chiral information from axially chiral binol‐derived phosphoramidites to diamine products in Pd‐catalyzed asymmetric diamination are presented. Through DFT studies, the origin of stereo‐ and regioselectivities in the asymmetric diamination of dienes is established (see figure).