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Mg‐Catalyzed Enantioselective Benzylic CH Bond Functionalization of Isoindolinones: Addition to Imines
Author(s) -
Suzuki Yudai,
Kanai Motomu,
Matsunaga Shigeki
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200821
Subject(s) - enantioselective synthesis , chemistry , catalysis , surface modification , aryl , combinatorial chemistry , organic chemistry , alkyl , medicinal chemistry
Access to chiral isoindolinones : The Mg‐catalyzed enantioselective benzylic CH bond functionalization of isoindolinones is described. A Bu 2 Mg/Schiff base catalyst (1:1) promoted the enantioselective addition of N ‐Boc‐isoindolinones to aryl, heteroaryl, alkenyl, and alkyl imines, giving 3‐substituted isoindolinones in 84–99 % ee and 50:50–91:9 d.r. (see scheme).