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Copper‐Catalyzed Formation of CO Bonds by Direct α‐CH Bond Activation of Ethers Using Stoichiometric Amounts of Peroxide in Batch and Continuous‐Flow Formats
Author(s) -
Kumar G. Sathish,
Pieber Bartholomäus,
Reddy K. Rajender,
Kappe C. Oliver
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200815
Subject(s) - peroxide , chemistry , catalysis , microreactor , acetal , stoichiometry , organic peroxide , copper , phenols , organic chemistry , polymer chemistry , combinatorial chemistry , copolymer , polymer
Peroxides and ethers in flow : 2‐Carbonyl‐substituted phenols and β‐ketoesters react safely with ethers in a microreactor environment using a copper catalyst and an organic peroxide (TBHP). This protocol results in unsymmetrical acetal scaffolds not easily available otherwise (see scheme).