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Salicylic‐Acid Derivatives as Antennae for Ratiometric Luminescent Probes Based on Lanthanide Complexes
Author(s) -
Terai Takuya,
Ito Hiroki,
Kikuchi Kazuya,
Nagano Tetsuo
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200610
Subject(s) - lanthanide , salicylic acid , luminescence , moiety , biomolecule , chemistry , combinatorial chemistry , antenna (radio) , luminescent measurements , nanotechnology , materials science , stereochemistry , organic chemistry , optoelectronics , biochemistry , computer science , ion , telecommunications
Long‐lived ratiometric sensors : Luminescent lanthanide complexes are widely used in time‐resolved assays of biomolecules, but most of the sensors with these complexes rely on single‐point intensity measurements. Herein, we introduce a simple strategy to create ratiometric probes by using salicylic‐acid derivatives as the antenna moiety of Tb 3+ complexes. As an example, a probe for alkaline phosphatase (ALP) was developed (see scheme).