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Artificial Electron Carriers for Photoenzymatic Synthesis under Visible Light
Author(s) -
Lee Sahng Ha,
Lee Hye Jung,
Won Keehoon,
Park Chan Beum
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200281
Subject(s) - nad+ kinase , cofactor , pyridine , chemistry , photochemistry , stereochemistry , biochemistry , combinatorial chemistry , computer science , enzyme , organic chemistry
NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3‐substituted pyridine ring have been investigated. 3‐Acetylpyridine adenine dinucleotide and 3‐pyridinealdehyde adenine dinucleotide were photochemically reduced much more efficiently than NAD, while their reduced products showed coenzyme activity comparable to natural NAD.