Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Coupling between Methylenecyclopropanes, Aldehydes, and Triethylborane with Retention of the Cyclopropane Ring | Zendy

Ogata Kenichi | Zendy; Shimada Daisuke | Zendy; Fukuzawa Shinichi | Zendy

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Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Coupling between Methylenecyclopropanes, Aldehydes, and Triethylborane with Retention of the Cyclopropane Ring

Author(s) -

Ogata Kenichi,

Shimada Daisuke,

Fukuzawa Shinichi

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201200271

Subject(s) - triethylborane , cyclopropane , stereoselectivity , nickel , ring (chemistry) , catalysis , chemistry , coupling (piping) , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy

Running rings : The first regio‐ and stereoselective reductive coupling between methylenecyclopropanes, aldehydes, and triethylborane with retention of the cyclopropane ring was achieved using a nickel–phosphine catalyst (see scheme). The reductive coupling reaction constructed a stereo‐defined cyclopropane ring with formation of a quaternary stereogenic carbon center.

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