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Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Coupling between Methylenecyclopropanes, Aldehydes, and Triethylborane with Retention of the Cyclopropane Ring
Author(s) -
Ogata Kenichi,
Shimada Daisuke,
Fukuzawa Shinichi
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200271
Subject(s) - triethylborane , cyclopropane , stereoselectivity , nickel , ring (chemistry) , catalysis , chemistry , coupling (piping) , medicinal chemistry , stereochemistry , organic chemistry , materials science , metallurgy
Running rings : The first regio‐ and stereoselective reductive coupling between methylenecyclopropanes, aldehydes, and triethylborane with retention of the cyclopropane ring was achieved using a nickel–phosphine catalyst (see scheme). The reductive coupling reaction constructed a stereo‐defined cyclopropane ring with formation of a quaternary stereogenic carbon center.