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Palladium‐Catalyzed Synthesis of Phthalazinones: Efficient Carbonylative Coupling of 2‐Bromobenzaldehydes and Hydrazines
Author(s) -
Wu XiaoFeng,
Neumann Helfried,
Neumann Stephan,
Beller Matthias
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200267
Subject(s) - palladium , variety (cybernetics) , catalysis , computer science , chemistry , carbonylation , scheme (mathematics) , combinatorial chemistry , organic chemistry , carbon monoxide , mathematics , artificial intelligence , mathematical analysis
Phthalazinones made easy! A new, straightforward methodology for the carbonylative synthesis of phthalazinones has been established. Starting from readily available 2‐bromobenzaldehydes or 2‐bromoacetophenone and hydrazines, a variety of phthalazinones have been produced in good isolated yields (see scheme).