Palladium‐Catalyzed Synthesis of Phthalazinones: Efficient Carbonylative Coupling of 2‐Bromobenzaldehydes and Hydrazines | Zendy

Wu XiaoFeng | Zendy; Neumann Helfried | Zendy; Neumann Stephan | Zendy; Beller Matthias | Zendy

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Palladium‐Catalyzed Synthesis of Phthalazinones: Efficient Carbonylative Coupling of 2‐Bromobenzaldehydes and Hydrazines

Author(s) -

Wu XiaoFeng,

Neumann Helfried,

Neumann Stephan,

Beller Matthias

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201200267

Subject(s) - palladium , variety (cybernetics) , catalysis , computer science , chemistry , carbonylation , scheme (mathematics) , combinatorial chemistry , organic chemistry , carbon monoxide , mathematics , artificial intelligence , mathematical analysis

Phthalazinones made easy! A new, straightforward methodology for the carbonylative synthesis of phthalazinones has been established. Starting from readily available 2‐bromobenzaldehydes or 2‐bromoacetophenone and hydrazines, a variety of phthalazinones have been produced in good isolated yields (see scheme).

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