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Iridium‐Catalyzed Enantioselective Hydrogenation of Alkenylboronic Esters
Author(s) -
Ganić Adnan,
Pfaltz Andreas
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200246
Subject(s) - iridium , enantioselective synthesis , ligand (biochemistry) , catalysis , asymmetric hydrogenation , chemistry , phosphinite , imidazoline receptor , combinatorial chemistry , pyridine , organic chemistry , biology , biochemistry , receptor , endocrinology
Choose the right ligand : An iridium complex derived from a phosphino–imidazoline ligand is a highly efficient catalyst for the asymmetric hydrogenation of terminal vinyl boronic esters (see scheme). On the other hand, trisubstituted alkenyl‐boronates can be reduced with high activity and good to excellent enantioselectivity employing a pyridine–phosphinite ligand.