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Iron Thiolate Complexes: Efficient Catalysts for Coupling Alkenyl Halides with Alkyl Grignard Reagents
Author(s) -
Cahiez Gérard,
Gager Olivier,
Buendia Julien,
Patinote Cindy
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200184
Subject(s) - halide , alkyl , reagent , catalysis , chemistry , stereoselectivity , solvent , grignard reagent , coupling (piping) , combinatorial chemistry , coupling reaction , medicinal chemistry , organic chemistry , polymer chemistry , materials science , metallurgy
Ironing out the kinks : Efficient new catalytic systems based on iron thiolates are described for the iron‐catalyzed cross‐coupling of alkyl Grignard reagents with alkenyl halides (see scheme). The reaction is highly chemo‐ and stereoselective. With this new procedure, the use of N ‐methylpyrrolidone as a co‐solvent is no longer required.