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A Functionally Selective Synthetic Mimic of the HIV‐1 Co‐receptor CXCR4
Author(s) -
Möbius Kalle,
Dürr Ralf,
Haußner Christina,
Dietrich Ursula,
Eichler Jutta
Publication year - 2012
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201200111
Subject(s) - human immunodeficiency virus (hiv) , cxcr4 , receptor , recombinant dna , computational biology , peptide , extracellular , computer science , biology , chemistry , microbiology and biotechnology , biochemistry , virology , gene , chemokine
Small and selective : A synthetically assembled CXCR4 mimetic peptide, which presents the three extracellular loops (ECLs) of this HIV‐1 co‐receptor, is able to discriminate between gp120 from X4‐ and R5‐tropic HIV‐1 in binding assays involving recombinant proteins, as well as in cellular infection assays.