ROS‐Inducible DNA Cross‐Linking Agent as a New Anticancer Prodrug Building Block | Zendy

Cao Sheng | Zendy; Wang Yibin | Zendy; Peng Xiaohua | Zendy

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ROS‐Inducible DNA Cross‐Linking Agent as a New Anticancer Prodrug Building Block

Author(s) -

Cao Sheng,

Wang Yibin,

Peng Xiaohua

Publication year - 2012

Publication title -

chemistry – a european journal

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.687

H-Index - 242

eISSN - 1521-3765

pISSN - 0947-6539

DOI - 10.1002/chem.201200075

Subject(s) - prodrug , block (permutation group theory) , dna , hydrogen peroxide , chemistry , alkylation , combinatorial chemistry , scheme (mathematics) , computer science , biochemistry , mathematics , catalysis , mathematical analysis , geometry

Down at the crossed code : Novel arylboronic ester and biarylboronic ester derivatives were synthesized. Compound 1 can be activated by hydrogen peroxide to release 2,5‐bis(trimethylammonium) benzyl‐1,4‐diol ( 2 ), which leads to interstrand cross‐link formation and DNA alkylation (see scheme). Compound 1 provides a novel building block for the development of H 2 O 2 ‐targeting anticancer prodrugs.

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