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Inside Cover: Optimization of the Antioxidant Activity of Hydroxy‐Substituted 4‐Thiaflavanes: A Proof‐of‐Concept Study (Chem. Eur. J. 44/2011)
Author(s) -
Viglianisi Caterina,
Bartolozzi Maria Grazia,
Pedulli Gian Franco,
Amorati Riccardo,
Menichetti Stefano
Publication year - 2011
Publication title -
chemistry – a european journal
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 1.687
H-Index - 242
eISSN - 1521-3765
pISSN - 0947-6539
DOI - 10.1002/chem.201190216
Subject(s) - chemistry , moiety , radical , bond dissociation energy , antioxidant , dissociation (chemistry) , sulfur , medicinal chemistry , computational chemistry , stereochemistry , organic chemistry
A new family of phenolic antioxidants in which the reactive phenolic group is ortho to the sulfur atom of a 4‐thiaflavane moiety has been prepared. The rate constants for the reaction with peroxyl radicals measured for these compounds, as well as the bond dissociation energies of the ArOH bond, are very similar to those measured for α‐tocopherol, the main component of vitamin E. In their Full Paper on page 12396 ff. , S. Menichetti, R. Amorati et al. describe how the stereoelectronic features triggered by the sulfur atom have been exploited to design this new class of compounds.